1-环丙基-6,7-二氟-1,4-二氢-8-甲氧基-4-氧代-3-喹啉羧酸 (CAS No.112811-72-0)
- 中文别名
- 吉米沙星中间体；吉米沙星母核；1-环丙基-6,7-二氟-8-甲氧基-4-氧代-1,4-二氢喹啉-3-羧酸
- 英文名称
- 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
- 分子式
- C14H11F2NO4
- InChIKey
- WQJZXSSAMGZVTM-UHFFFAOYSA-N
- 所属类别
- 中间体
- 物化性质
- 类白色至淡黄色结晶性粉末，无臭，几乎不溶于水，微溶于甲醇、乙醇，溶于二甲基甲酰胺、二甲基亚砜等强极性有机溶剂。熔点约255-260℃（分解）。
- 外观
- 类白色至淡黄色结晶性粉末
- 熔点
- 255-260℃（分解）
English description（英文原文，共 1339 字符）
Product Name:1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
English Name:1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
CAS No.:112811-72-0
Aliases:Gemifloxacin intermediate, Gemifloxacin mother nucleus, 1-Cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
Molecular Formula:C14H11F2NO4
Physical Properties:Off-white to light yellow crystalline powder, odorless, practically insoluble in water, slightly soluble in methanol and ethanol, soluble in strong polar organic solvents such as dimethylformamide and dimethyl sulfoxide. Melting point: approximately 255-260°C (decomposes).
Uses:This product is a key intermediate in the synthesis of gemifloxacin. Gemifloxacin is a fourth-generation fluoroquinolone broad-spectrum antibacterial agent with good activity against both Gram-positive and Gram-negative bacteria, clinically used for the treatment of acute exacerbations of chronic bronchitis and community-acquired pneumonia. This intermediate can be converted to gemifloxacin API through side-chain condensation and hydrolysis steps.
Technical Specifications:
Appearance: off-white to light yellow crystalline powder
Assay (HPLC): ≥98.0%
Loss on drying: ≤0.5%
Melting point: 255-260°C (decomposes)
Residue on ignition: ≤0.1%
English Name:1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
CAS No.:112811-72-0
Aliases:Gemifloxacin intermediate, Gemifloxacin mother nucleus, 1-Cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
Molecular Formula:C14H11F2NO4
Physical Properties:Off-white to light yellow crystalline powder, odorless, practically insoluble in water, slightly soluble in methanol and ethanol, soluble in strong polar organic solvents such as dimethylformamide and dimethyl sulfoxide. Melting point: approximately 255-260°C (decomposes).
Uses:This product is a key intermediate in the synthesis of gemifloxacin. Gemifloxacin is a fourth-generation fluoroquinolone broad-spectrum antibacterial agent with good activity against both Gram-positive and Gram-negative bacteria, clinically used for the treatment of acute exacerbations of chronic bronchitis and community-acquired pneumonia. This intermediate can be converted to gemifloxacin API through side-chain condensation and hydrolysis steps.
Technical Specifications:
Appearance: off-white to light yellow crystalline powder
Assay (HPLC): ≥98.0%
Loss on drying: ≤0.5%
Melting point: 255-260°C (decomposes)
Residue on ignition: ≤0.1%
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常见问题
- 1-环丙基-6,7-二氟-1,4-二氢-8-甲氧基-4-氧代-3-喹啉羧酸的 CAS 号是多少？
- 1-环丙基-6,7-二氟-1,4-二氢-8-甲氧基-4-氧代-3-喹啉羧酸的 CAS 号是 112811-72-0。
- 1-环丙基-6,7-二氟-1,4-二氢-8-甲氧基-4-氧代-3-喹啉羧酸的分子式和分子量是什么？
- 1-环丙基-6,7-二氟-1,4-二氢-8-甲氧基-4-氧代-3-喹啉羧酸的分子式为 C14H11F2NO4。
- 1-环丙基-6,7-二氟-1,4-二氢-8-甲氧基-4-氧代-3-喹啉羧酸的英文名称是什么？
- 1-环丙基-6,7-二氟-1,4-二氢-8-甲氧基-4-氧代-3-喹啉羧酸的英文名称为 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid。
- 1-环丙基-6,7-二氟-1,4-二氢-8-甲氧基-4-氧代-3-喹啉羧酸还有哪些别名？
- 1-环丙基-6,7-二氟-1,4-二氢-8-甲氧基-4-氧代-3-喹啉羧酸又称 吉米沙星中间体、吉米沙星母核、1-环丙基-6,7-二氟-8-甲氧基-4-氧代-1,4-二氢喹啉-3-羧酸。
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