2-氨基-3-(4-BOC-哌嗪)基吡嗪 (CAS No.1208542-95-3)

Product Name:tert-Butyl 4-(3-aminopyrazin-2-yl)piperazine-1-carboxylate

English Name:tert-Butyl 4-(3-aminopyrazin-2-yl)piperazine-1-carboxylate

CAS No.:1208542-95-3

Aliases:tert-butyl 4-(3-aminopyrazin-2-yl)piperazine-1-carboxylate, 2-amino-3-(4-Boc-piperazin-1-yl)pyrazine, 4-(3-aminopyrazin-2-yl)piperazine-1-carboxylic acid tert-butyl ester

Molecular Formula:C13H21N5O2

Physical Properties:Off-white to light yellow crystalline powder; melting point approximately 150–160 °C (dec.). Soluble in dichloromethane, chloroform, DMF and other organic solvents; sparingly soluble in methanol and ethanol; almost insoluble in water. Stable at room temperature. The Boc group can be removed under acidic conditions. Store sealed, protected from light, and keep dry at 2–8 °C.

Uses:This product is an important pharmaceutical intermediate containing a Boc-protected piperazine and an aminopyrazine moiety, mainly used for the synthesis of kinase inhibitors and receptor modulators. It can be utilized to construct the core scaffold of CDK, EGFR and other kinase inhibitors in drug discovery. After removal of the Boc protecting group, further derivatization reactions such as acylation or sulfonylation can be performed.

Technical Specifications:

Molecular formula: C13H21N5O2

Molecular weight: 279.34

Purity: ≥98% (HPLC)

Appearance: off-white to light yellow crystalline powder

Melting point: approximately 150–160 °C (dec.)

Storage: keep sealed and protected from light at 2–8 °C