ML-265 (CAS No.1221186-53-3)
- 物化性质
- 白色至类白色固体粉末。溶于DMSO、DMF等有机溶剂，微溶于乙醇，几乎不溶于水。建议-20°C干燥避光密封保存，避免反复冻融。
- 外观
- 白色至类白色固体粉末
- 溶解性
- DMSO可溶(≥10 mg/mL)，微溶于乙醇，几乎不溶于水
English description（英文原文，共 1329 字符）
Product Name:ML-265
English Name:ML-265
CAS No.:1221186-53-3
Aliases:ML265, PKM2 activator ML-265, Pyruvate kinase M2 activator ML-265
Molecular Formula:C17H16N4O2S2
Physical Properties:White to off-white solid powder. Soluble in DMSO, DMF and other organic solvents; slightly soluble in ethanol; practically insoluble in water. Store at -20°C in a dry, sealed container protected from light; avoid repeated freeze-thaw cycles.
Uses:ML-265 is a potent and highly selective activator of pyruvate kinase M2 (PKM2), which enhances its catalytic activity by stabilizing the tetrameric conformation, with an AC50 of approximately 92 nM for PKM2 activation in vitro and no significant activity against PKM1, PKR or PKL isoforms. This compound is commonly used in cancer metabolism research to elucidate the molecular regulatory mechanisms of the Warburg effect (aerobic glycolysis), the functional role of PKM2 in tumor cell proliferation and survival, and to explore therapeutic strategies targeting the glycolytic pathway in tumors.
Technical Specifications:
Purity (HPLC): ≥98%
Molecular weight: 372.46
Appearance: white to off-white solid powder
Solubility: soluble in DMSO (≥10 mg/mL), slightly soluble in ethanol, practically insoluble in water
Storage: store at -20°C, protected from light, in a dry sealed container
English Name:ML-265
CAS No.:1221186-53-3
Aliases:ML265, PKM2 activator ML-265, Pyruvate kinase M2 activator ML-265
Molecular Formula:C17H16N4O2S2
Physical Properties:White to off-white solid powder. Soluble in DMSO, DMF and other organic solvents; slightly soluble in ethanol; practically insoluble in water. Store at -20°C in a dry, sealed container protected from light; avoid repeated freeze-thaw cycles.
Uses:ML-265 is a potent and highly selective activator of pyruvate kinase M2 (PKM2), which enhances its catalytic activity by stabilizing the tetrameric conformation, with an AC50 of approximately 92 nM for PKM2 activation in vitro and no significant activity against PKM1, PKR or PKL isoforms. This compound is commonly used in cancer metabolism research to elucidate the molecular regulatory mechanisms of the Warburg effect (aerobic glycolysis), the functional role of PKM2 in tumor cell proliferation and survival, and to explore therapeutic strategies targeting the glycolytic pathway in tumors.
Technical Specifications:
Purity (HPLC): ≥98%
Molecular weight: 372.46
Appearance: white to off-white solid powder
Solubility: soluble in DMSO (≥10 mg/mL), slightly soluble in ethanol, practically insoluble in water
Storage: store at -20°C, protected from light, in a dry sealed container
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常见问题
- ML-265的 CAS 号是多少？
- ML-265的 CAS 号是 1221186-53-3。
- ML-265的分子式和分子量是什么？
- ML-265的分子式为 C17H16N4O2S2，分子量约 372.46。
- ML-265的英文名称是什么？
- ML-265的英文名称为 ML-265。
- ML-265还有哪些别名？
- ML-265又称 ML265、PKM2激活剂ML-265、丙酮酸激酶M2激活剂ML-265。
- ML-265有哪些供应商和生产厂家？
- 掌上化工当前收录 1 条ML-265供应报价，来自 1 家供应商，可按地区、纯度、级别筛选对比。
- ML-265的供应商主要分布在哪些地区？
- ML-265的供应商主要分布在 上海市（1 条） 等地。
- ML-265有哪些级别可选？
- 平台上ML-265的供应级别包括 工业级。
- ML-265的报价单位是什么？
- ML-265的报价单位主要有 千克。
- 哪里可以查到ML-265的价格？
- 掌上化工ML-265产品页汇总了各供应商的最新报价与规格，地址：/chemicals/1221186-53-3/。部分供应商价格为电议，可通过页面上的询价功能直接获取。
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