N2-iBu-2'-O-4'-C-锁核酸(LNA)-Gr-CE-亚磷酰胺 (CAS No.206055-77-8)
- 中文别名
- LNA-G亚磷酰胺；N2-iBu-5'-O-DMT-2'-O-4'-C-锁核酸(LNA)-G-CE-亚磷酰胺；2'-O,4'-C-亚甲基鸟苷亚磷酰胺
- 英文名称
- N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-O,4'-C-methylene-LNA-guanosine CE Phosphoramidite
- 分子式
- C45H54N7O9P
- InChIKey
- UUBFSNDSLDOIDQ-NIQOLRRHSA-N
- 所属类别
- 中间体
- 物化性质
- 白色至类白色泡沫状固体；易溶于乙腈、二氯甲烷、DMF、四氢呋喃等有机溶剂，微溶于甲醇；对湿气和酸敏感，在无水条件下稳定；需于-20℃干燥、避光、惰性气体保护下保存。
- 外观
- 白色至类白色粉末/泡沫状固体
- 纯度
- ≥98%（HPLC）
- 溶解性
- 易溶于乙腈、二氯甲烷、四氢呋喃等有机溶剂
- 贮存条件
- -20℃以下，干燥避光，氮气或氩气保护
English description（英文原文，共 1518 字符）
Product Name:N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-O,4'-C-methylene-LNA-guanosine CE Phosphoramidite
English Name:N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-O,4'-C-methylene-LNA-guanosine CE Phosphoramidite
CAS No.:206055-77-8
Aliases:LNA-G phosphoramidite, N2-iBu-5'-O-DMT-2'-O-4'-C-LNA-G-CE phosphoramidite, 2'-O,4'-C-methylene guanosine phosphoramidite
Molecular Formula:C45H54N7O9P
Physical Properties:White to off-white foamy solid; soluble in acetonitrile, dichloromethane, DMF, THF and other organic solvents, slightly soluble in methanol; sensitive to moisture and acids, stable under anhydrous conditions; store at -20°C, protected from light and moisture, under inert gas.
Uses:Used as a locked nucleic acid (LNA) modified guanine phosphoramidite monomer for solid-phase oligonucleotide synthesis. Incorporation of LNA-G modifications into DNA/RNA oligonucleotide strands significantly enhances hybridization affinity and thermal stability toward complementary sequences, and increases nuclease resistance. It is widely applied in antisense oligonucleotides (ASO), siRNA, miRNA inhibitors, qPCR probes, and high-sensitivity nucleic acid detection.
Technical Specifications:
Appearance: White to off-white powder/foamy solid
Purity: ≥98% (HPLC)
Molecular formula/weight: C45H54N7O9P / 868.0
Solubility: Readily soluble in acetonitrile, dichloromethane, tetrahydrofuran and other organic solvents
Storage: Store below -20°C, dry and protected from light, under nitrogen or argon atmosphere
English Name:N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-O,4'-C-methylene-LNA-guanosine CE Phosphoramidite
CAS No.:206055-77-8
Aliases:LNA-G phosphoramidite, N2-iBu-5'-O-DMT-2'-O-4'-C-LNA-G-CE phosphoramidite, 2'-O,4'-C-methylene guanosine phosphoramidite
Molecular Formula:C45H54N7O9P
Physical Properties:White to off-white foamy solid; soluble in acetonitrile, dichloromethane, DMF, THF and other organic solvents, slightly soluble in methanol; sensitive to moisture and acids, stable under anhydrous conditions; store at -20°C, protected from light and moisture, under inert gas.
Uses:Used as a locked nucleic acid (LNA) modified guanine phosphoramidite monomer for solid-phase oligonucleotide synthesis. Incorporation of LNA-G modifications into DNA/RNA oligonucleotide strands significantly enhances hybridization affinity and thermal stability toward complementary sequences, and increases nuclease resistance. It is widely applied in antisense oligonucleotides (ASO), siRNA, miRNA inhibitors, qPCR probes, and high-sensitivity nucleic acid detection.
Technical Specifications:
Appearance: White to off-white powder/foamy solid
Purity: ≥98% (HPLC)
Molecular formula/weight: C45H54N7O9P / 868.0
Solubility: Readily soluble in acetonitrile, dichloromethane, tetrahydrofuran and other organic solvents
Storage: Store below -20°C, dry and protected from light, under nitrogen or argon atmosphere
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常见问题
- N2-iBu-2'-O-4'-C-锁核酸(LNA)-Gr-CE-亚磷酰胺的 CAS 号是多少？
- N2-iBu-2'-O-4'-C-锁核酸(LNA)-Gr-CE-亚磷酰胺的 CAS 号是 206055-77-8。
- N2-iBu-2'-O-4'-C-锁核酸(LNA)-Gr-CE-亚磷酰胺的分子式和分子量是什么？
- N2-iBu-2'-O-4'-C-锁核酸(LNA)-Gr-CE-亚磷酰胺的分子式为 C45H54N7O9P。
- N2-iBu-2'-O-4'-C-锁核酸(LNA)-Gr-CE-亚磷酰胺的英文名称是什么？
- N2-iBu-2'-O-4'-C-锁核酸(LNA)-Gr-CE-亚磷酰胺的英文名称为 N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-O,4'-C-methylene-LNA-guanosine CE Phosphoramidite。
- N2-iBu-2'-O-4'-C-锁核酸(LNA)-Gr-CE-亚磷酰胺还有哪些别名？
- N2-iBu-2'-O-4'-C-锁核酸(LNA)-Gr-CE-亚磷酰胺又称 LNA-G亚磷酰胺、N2-iBu-5'-O-DMT-2'-O-4'-C-锁核酸(LNA)-G-CE-亚磷酰胺、2'-O,4'-C-亚甲基鸟苷亚磷酰胺。
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