氯氮平N-氧化盐酸;氯氮平N-氧化物二盐酸盐 (CAS No.2250025-93-3)

Product Name:Clozapine N-oxide dihydrochloride

English Name:Clozapine N-oxide dihydrochloride

CAS No.:2250025-93-3

Aliases:Clozapine N-oxide hydrochloride, Clozapine N-oxide bis(hydrochloride), CNO dihydrochloride

Molecular Formula:C18H21Cl3N4O

Physical Properties:White to off-white crystalline powder; readily soluble in water, methanol and DMSO, sparingly soluble in isopropanol; stable under dry, light-protected and low-temperature storage conditions. As the major active metabolite of clozapine in vivo, it belongs to the class of tertiary amine N-oxides and exhibits good aqueous solubility, facilitating convenient in vitro pharmacological manipulation.

Uses:As the predominant active metabolite of clozapine in vivo, this compound serves as a key analytical standard in pharmacokinetic and toxicological studies to investigate the N-oxidative metabolic pathway of clozapine. It is widely employed in therapeutic drug monitoring (TDM) of clozapine for the preparation of quality control samples, as well as in neuropsychopharmacological research to evaluate the pharmacological effects and adverse reactions associated with N-oxide metabolites. Its stable N-oxide structure is also applicable in studies of metabolic enzyme activities such as CYP1A2 and CYP3A4.

Technical Specifications:

Purity: ≥95% by HPLC area normalization method

Molecular weight: 415.75 g/mol

Solubility: readily soluble in water, methanol and DMSO; sparingly soluble in isopropanol

Appearance: white to off-white crystalline powder

Storage: sealed and stored protected from light at -20°C; long-term stability under recommended conditions