地塞米松9,11-环氧 (CAS No.24916-90-3)
- 中文别名
- 9β,11β-环氧-17α,21-二羟基-16α-甲基孕甾-1,4-二烯-3,20-二酮；地塞米松环氧物；环氧地塞米松
- 英文名称
- Dexamethasone 9,11-epoxide
- 分子式
- C22H28O5
- InChIKey
- GBDXNHBVYAMODG-QDBZYVRYSA-N
- 所属类别
- 中间体
- 物化性质
- 白色至类白色结晶性粉末，无臭，味微苦。在氯仿、二氯甲烷中易溶，在甲醇、乙醇中微溶，在水中几乎不溶。熔点约为230～235℃（分解）。
- 技术参数
- 含量（HPLC）≥98.0%
- 熔点
- 230～235℃（分解）
English description（英文原文，共 1130 字符）
Product Name:Dexamethasone 9,11-epoxide
English Name:Dexamethasone 9,11-epoxide
CAS No.:24916-90-3
Aliases:9β,11β-Epoxy-17α,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione, Epoxydexamethasone
Molecular Formula:C22H28O5
Physical Properties:White to off-white crystalline powder, odorless, slightly bitter taste. Freely soluble in chloroform and dichloromethane, sparingly soluble in methanol and ethanol, practically insoluble in water. Melting point approximately 230–235°C (decomposition).
Uses:This product is a key intermediate in the synthesis of dexamethasone, mainly used in the pharmaceutical industry to prepare steroidal hormone drugs such as dexamethasone, dexamethasone sodium phosphate, and dexamethasone acetate. Through ring-opening of its epoxide ring, it can be directed to introduce 9α-fluoro and 11β-hydroxy groups, serving as an important precursor for the synthesis of fluorinated glucocorticoids.
Technical Specifications:
Assay (HPLC) ≥ 98.0%
Melting point: 230–235°C (decomposition)
Specific rotation [α]D20: +100° to +110° (c=1, chloroform)
Loss on drying: ≤ 0.5%
Residue on ignition: ≤ 0.1%
English Name:Dexamethasone 9,11-epoxide
CAS No.:24916-90-3
Aliases:9β,11β-Epoxy-17α,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione, Epoxydexamethasone
Molecular Formula:C22H28O5
Physical Properties:White to off-white crystalline powder, odorless, slightly bitter taste. Freely soluble in chloroform and dichloromethane, sparingly soluble in methanol and ethanol, practically insoluble in water. Melting point approximately 230–235°C (decomposition).
Uses:This product is a key intermediate in the synthesis of dexamethasone, mainly used in the pharmaceutical industry to prepare steroidal hormone drugs such as dexamethasone, dexamethasone sodium phosphate, and dexamethasone acetate. Through ring-opening of its epoxide ring, it can be directed to introduce 9α-fluoro and 11β-hydroxy groups, serving as an important precursor for the synthesis of fluorinated glucocorticoids.
Technical Specifications:
Assay (HPLC) ≥ 98.0%
Melting point: 230–235°C (decomposition)
Specific rotation [α]D20: +100° to +110° (c=1, chloroform)
Loss on drying: ≤ 0.5%
Residue on ignition: ≤ 0.1%
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常见问题
- 地塞米松9,11-环氧的 CAS 号是多少？
- 地塞米松9,11-环氧的 CAS 号是 24916-90-3。
- 地塞米松9,11-环氧的分子式和分子量是什么？
- 地塞米松9,11-环氧的分子式为 C22H28O5。
- 地塞米松9,11-环氧的英文名称是什么？
- 地塞米松9,11-环氧的英文名称为 Dexamethasone 9,11-epoxide。
- 地塞米松9,11-环氧还有哪些别名？
- 地塞米松9,11-环氧又称 9β,11β-环氧-17α,21-二羟基-16α-甲基孕甾-1,4-二烯-3,20-二酮、地塞米松环氧物、环氧地塞米松。
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