(2S,4S)-FMOC-HOPRO(4-FMOCNH)-OH (CAS No.252029-00-8)

Product Name:Fmoc-(2S,4S)-4-(Fmoc-amino)pyrrolidine-2-carboxylic acid

English Name:Fmoc-(2S,4S)-4-(Fmoc-amino)pyrrolidine-2-carboxylic acid

CAS No.:252029-00-8

Aliases:Fmoc-(2S,4S)-4-(Fmoc-amino)proline, (2S,4S)-1-Fmoc-4-(Fmoc-amino)pyrrolidine-2-carboxylic acid

Molecular Formula:C36H32N2O6

Physical Properties:White to off-white solid powder; molecular weight 588.65; freely soluble in organic solvents such as DMF, DMSO, dichloromethane and methanol, insoluble in water; optically active with (2S,4S) configuration; store sealed, dry and protected from light at 2–8 °C.

Uses:This Fmoc-protected amino acid derivative bearing a 4-aminoproline scaffold is widely used in solid-phase peptide synthesis (SPPS) for the preparation of peptides and peptidomimetics containing 4-substituted proline residues. As a conformationally constrained amino acid building block, it is employed in the design of peptide drugs with enhanced metabolic stability and bioactivity, protein mimics and collagen analogs. It also serves as a key intermediate for constructing diverse compound libraries in medicinal chemistry and chemical biology research.

Technical Specifications:

Purity: ≥97% (HPLC)

Molecular formula: C36H32N2O6; molecular weight: 588.65

Appearance: white to off-white solid powder

Solubility: soluble in DMF, DMSO, dichloromethane and other organic solvents; insoluble in water

Storage: keep sealed, dry and protected from light at 2–8 °C