佐芬普利拉 (CAS No.75176-37-3)
- 中文别名
- 佐芬普利酸；佐芬普利活性代谢物；(2S)-1-[(2S)-3-巯基-2-甲基丙酰基]-4-(苯硫基)吡咯烷-2-羧酸
- 英文名称
- Zofenoprilat
- 分子式
- C15H19NO3S2
- 所属类别
- 试剂实验设备
- 物化性质
- 白色至类白色结晶性粉末。分子量为325.45，密度约1.3 g/cm³（估算值）。含有游离巯基，对光和空气敏感，易氧化为二硫化物。易溶于二甲基亚砜（DMSO）、甲醇、乙醇，微溶于水，溶于稀碱溶液。羧基pKa约3.8，巯基pKa约9.8。
- 外观
- 白色至类白色结晶性粉末。
- 溶解性
- 易溶于DMSO、甲醇，微溶于水，溶于稀碱液。
- 储存条件
- -20℃密封避光，充氮保存。
English description（英文原文，共 1417 字符）
Product Name:Zofenoprilat
English Name:Zofenoprilat
CAS No.:75176-37-3
Aliases:Zofenopril acid, Zofenopril active metabolite, (2S)-1-[(2S)-3-Mercapto-2-methylpropanoyl]-4-(phenylsulfanyl)pyrrolidine-2-carboxylic acid
Molecular Formula:C15H19NO3S2
Physical Properties:White to off-white crystalline powder. Molecular weight: 325.45; density: approximately 1.3 g/cm³ (estimated). Contains a free sulfhydryl group; sensitive to light and air, readily oxidized to disulfides. Freely soluble in DMSO, methanol and ethanol; slightly soluble in water; soluble in dilute alkaline solutions. pKa: carboxyl approximately 3.8, thiol approximately 9.8.
Uses:Zofenoprilat is the active metabolite of the angiotensin-converting enzyme (ACE) inhibitor prodrug zofenopril in vivo. It inhibits ACE, blocking the conversion of angiotensin I to angiotensin II and reducing aldosterone secretion, thereby relaxing blood vessels and lowering blood pressure. It is commonly used in pharmacological research related to hypertension and heart failure, and as a reference standard for studying the metabolic pathways of zofenopril.
Technical Specifications:
Purity (HPLC): ≥98%.
Appearance: white to off-white crystalline powder.
Solubility: freely soluble in DMSO and methanol, slightly soluble in water, soluble in dilute alkaline solutions.
Storage: sealed, protected from light, under nitrogen at -20°C.
Loss on drying: ≤0.5%.
English Name:Zofenoprilat
CAS No.:75176-37-3
Aliases:Zofenopril acid, Zofenopril active metabolite, (2S)-1-[(2S)-3-Mercapto-2-methylpropanoyl]-4-(phenylsulfanyl)pyrrolidine-2-carboxylic acid
Molecular Formula:C15H19NO3S2
Physical Properties:White to off-white crystalline powder. Molecular weight: 325.45; density: approximately 1.3 g/cm³ (estimated). Contains a free sulfhydryl group; sensitive to light and air, readily oxidized to disulfides. Freely soluble in DMSO, methanol and ethanol; slightly soluble in water; soluble in dilute alkaline solutions. pKa: carboxyl approximately 3.8, thiol approximately 9.8.
Uses:Zofenoprilat is the active metabolite of the angiotensin-converting enzyme (ACE) inhibitor prodrug zofenopril in vivo. It inhibits ACE, blocking the conversion of angiotensin I to angiotensin II and reducing aldosterone secretion, thereby relaxing blood vessels and lowering blood pressure. It is commonly used in pharmacological research related to hypertension and heart failure, and as a reference standard for studying the metabolic pathways of zofenopril.
Technical Specifications:
Purity (HPLC): ≥98%.
Appearance: white to off-white crystalline powder.
Solubility: freely soluble in DMSO and methanol, slightly soluble in water, soluble in dilute alkaline solutions.
Storage: sealed, protected from light, under nitrogen at -20°C.
Loss on drying: ≤0.5%.
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常见问题
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- 佐芬普利拉的 CAS 号是 75176-37-3。
- 佐芬普利拉的分子式和分子量是什么？
- 佐芬普利拉的分子式为 C15H19NO3S2。
- 佐芬普利拉的英文名称是什么？
- 佐芬普利拉的英文名称为 Zofenoprilat。
- 佐芬普利拉还有哪些别名？
- 佐芬普利拉又称 佐芬普利酸、佐芬普利活性代谢物、(2S)-1-[(2S)-3-巯基-2-甲基丙酰基]-4-(苯硫基)吡咯烷-2-羧酸。
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