2-甲氧基-4-[4-(4-甲基-1-哌嗪基]-盐酸苯胺 (CAS No.761440-75-9)

Product Name:2-Methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]aniline

English Name:2-Methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]aniline

CAS No.:761440-75-9

Aliases:4-(4-Methylpiperazin-1-yl)-1-(4-amino-3-methoxyphenyl)piperidine, 1-(4-Amino-3-methoxyphenyl)-4-(4-methylpiperazin-1-yl)piperidine

Molecular Formula:C17H28N4O

Physical Properties:Off-white to pale yellow crystalline powder. Melting point: 125–135 °C. Predicted boiling point: 450.6±45.0 °C (760 mmHg), predicted flash point: 226.9±30.0 °C, predicted density: 1.12±0.06 g/cm³. Freely soluble in methanol, ethanol, dichloromethane and other organic solvents; slightly soluble in water. Prone to oxidative discoloration when exposed to light and air; store sealed, protected from light, at low temperature.

Uses:This product is a piperazinylpiperidine-containing arylamine compound and serves as a key intermediate in the synthesis of benzisoxazole antipsychotic drugs such as risperidone and paliperidone. The primary aromatic amino group participates in acylation, condensation, or heterocyclization reactions to construct the core scaffold of drug molecules. It is also widely used in the research and development of piperazine-based pharmaceuticals and organic synthesis.

Technical Specifications:

Appearance: off-white to pale yellow crystalline powder

Purity (HPLC): ≥98.0%

Water content (Karl Fischer): ≤0.5%

Melting point: 125–135 °C

Molecular weight: 304.43 g/mol