1-[5-[(3,4-二氢-4-氧代-1-酞嗪基)甲基]-2-氟苯甲酰基]哌嗪 (CAS No.763111-47-3)
![1-[5-[(3,4-二氢-4-氧代-1-酞嗪基)甲基]-2-氟苯甲酰基]哌嗪 763111-47-3](/media/business/equip_covers/equip_59230.png)
- 中文别名
- 4-(4-氟-3-(哌嗪-1-羰基)苄基)酞嗪-1(2H)-酮；帕唑帕尼中间体
- 英文名称
- 4-(4-fluoro-3-(piperazine-1-carbonyl)benzyl)phthalazin-1(2H)-one
- 分子式
- C20H19FN4O2
- 分子量
- 366.39
- 所属类别
- 试剂实验设备
- 物化性质
- 类白色至淡黄色结晶性粉末，熔点为215-220℃（分解）。可溶于二甲基亚砜、N,N-二甲基甲酰胺和甲醇，微溶于乙醇，几乎不溶于水。密度约为1.3 g/cm³。需在2-8℃避光、密封、干燥条件下储存。
- 熔点
- 215-220℃（分解）
- 纯度
- ≥98%（HPLC）
- 储存条件
- 2-8℃，避光密封、干燥保存
- 溶解性
- 溶于DMSO、DMF，微溶于甲醇，几乎不溶于水
English description（英文原文，共 1398 字符）
Product Name:4-(4-fluoro-3-(piperazine-1-carbonyl)benzyl)phthalazin-1(2H)-one
English Name:4-(4-fluoro-3-(piperazine-1-carbonyl)benzyl)phthalazin-1(2H)-one
CAS No.:763111-47-3
Aliases:1-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)methyl]-2-fluorobenzoyl]piperazine, Pazopanib intermediate
Molecular Formula:C20H19FN4O2
Physical Properties:Off-white to pale yellow crystalline powder; melting point 215-220°C (decomposition). Soluble in dimethyl sulfoxide, N,N-dimethylformamide and methanol, sparingly soluble in ethanol, practically insoluble in water. Density approximately 1.3 g/cm³. Store at 2-8°C, protected from light, sealed and dry.
Uses:This compound is a key intermediate for pazopanib, a multi-targeted tyrosine kinase inhibitor used to treat advanced renal cell carcinoma and soft tissue sarcoma. The phthalazinone-piperazine moiety is the core pharmacophore for VEGFR inhibitory activity; the purity of this intermediate directly affects the quality and safety of the final drug. It can also serve as an important starting material for synthesizing other kinase inhibitor drugs bearing the phthalazinone skeleton.
Technical Specifications:
Melting point: 215-220°C (decomp.)
Molecular weight: 366.39
Purity: ≥98% (HPLC)
Storage: keep at 2-8°C, protected from light, sealed and dry
Solubility: soluble in DMSO and DMF, sparingly soluble in methanol, practically insoluble in water
English Name:4-(4-fluoro-3-(piperazine-1-carbonyl)benzyl)phthalazin-1(2H)-one
CAS No.:763111-47-3
Aliases:1-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)methyl]-2-fluorobenzoyl]piperazine, Pazopanib intermediate
Molecular Formula:C20H19FN4O2
Physical Properties:Off-white to pale yellow crystalline powder; melting point 215-220°C (decomposition). Soluble in dimethyl sulfoxide, N,N-dimethylformamide and methanol, sparingly soluble in ethanol, practically insoluble in water. Density approximately 1.3 g/cm³. Store at 2-8°C, protected from light, sealed and dry.
Uses:This compound is a key intermediate for pazopanib, a multi-targeted tyrosine kinase inhibitor used to treat advanced renal cell carcinoma and soft tissue sarcoma. The phthalazinone-piperazine moiety is the core pharmacophore for VEGFR inhibitory activity; the purity of this intermediate directly affects the quality and safety of the final drug. It can also serve as an important starting material for synthesizing other kinase inhibitor drugs bearing the phthalazinone skeleton.
Technical Specifications:
Melting point: 215-220°C (decomp.)
Molecular weight: 366.39
Purity: ≥98% (HPLC)
Storage: keep at 2-8°C, protected from light, sealed and dry
Solubility: soluble in DMSO and DMF, sparingly soluble in methanol, practically insoluble in water
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常见问题
- 1-[5-[(3,4-二氢-4-氧代-1-酞嗪基)甲基]-2-氟苯甲酰基]哌嗪的 CAS 号是多少？
- 1-[5-[(3,4-二氢-4-氧代-1-酞嗪基)甲基]-2-氟苯甲酰基]哌嗪的 CAS 号是 763111-47-3。
- 1-[5-[(3,4-二氢-4-氧代-1-酞嗪基)甲基]-2-氟苯甲酰基]哌嗪的分子式和分子量是什么？
- 1-[5-[(3,4-二氢-4-氧代-1-酞嗪基)甲基]-2-氟苯甲酰基]哌嗪的分子式为 C20H19FN4O2，分子量约 366.39。
- 1-[5-[(3,4-二氢-4-氧代-1-酞嗪基)甲基]-2-氟苯甲酰基]哌嗪的英文名称是什么？
- 1-[5-[(3,4-二氢-4-氧代-1-酞嗪基)甲基]-2-氟苯甲酰基]哌嗪的英文名称为 4-(4-fluoro-3-(piperazine-1-carbonyl)benzyl)phthalazin-1(2H)-one。
- 1-[5-[(3,4-二氢-4-氧代-1-酞嗪基)甲基]-2-氟苯甲酰基]哌嗪还有哪些别名？
- 1-[5-[(3,4-二氢-4-氧代-1-酞嗪基)甲基]-2-氟苯甲酰基]哌嗪又称 4-(4-氟-3-(哌嗪-1-羰基)苄基)酞嗪-1(2H)-酮、帕唑帕尼中间体。
- 1-[5-[(3,4-二氢-4-氧代-1-酞嗪基)甲基]-2-氟苯甲酰基]哌嗪有哪些供应商和生产厂家？
- 掌上化工当前收录 1 条1-[5-[(3,4-二氢-4-氧代-1-酞嗪基)甲基]-2-氟苯甲酰基]哌嗪供应报价，来自 1 家供应商，可按地区、纯度、级别筛选对比。
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- 1-[5-[(3,4-二氢-4-氧代-1-酞嗪基)甲基]-2-氟苯甲酰基]哌嗪的供应商主要分布在 上海市（1 条） 等地。
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- 平台上1-[5-[(3,4-二氢-4-氧代-1-酞嗪基)甲基]-2-氟苯甲酰基]哌嗪的供应级别包括 工业级。
- 1-[5-[(3,4-二氢-4-氧代-1-酞嗪基)甲基]-2-氟苯甲酰基]哌嗪的报价单位是什么？
- 1-[5-[(3,4-二氢-4-氧代-1-酞嗪基)甲基]-2-氟苯甲酰基]哌嗪的报价单位主要有 千克。
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- 掌上化工1-[5-[(3,4-二氢-4-氧代-1-酞嗪基)甲基]-2-氟苯甲酰基]哌嗪产品页汇总了各供应商的最新报价与规格，地址：/chemicals/763111-47-3/。部分供应商价格为电议，可通过页面上的询价功能直接获取。
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