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2S,4R-4-[[(1,1-DIMETHYLETHYL)DIMETHYLSILYL]OXY]-N- (933787-2 (CAS No.933787-22-5)

2S,4R-4-[[(1,1-DIMETHYLETHYL)DIMETHYLSILYL]OXY]-N- (933787-2 933787-22-5
中文别名
(2S,4R)-4-(叔丁基二甲基硅氧基)-N-[(1S,2S)-2-羟基-1,2-二苯基乙基]吡咯烷-2-甲酰胺;TBS保护的(2S,4R)-4-羟基脯氨酸酰胺衍生物
英文名称
2S,4R-4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-N-[(1S,2S)-2-hydroxy-1,2-diphenylethyl]-2-pyrrolidinecarboxamide
分子式
C25H36N2O3Si
所属类别
试剂实验设备
物化性质
类白色至白色结晶粉末,分子量440.65。可溶于二氯甲烷、氯仿、乙酸乙酯、甲醇等有机溶剂,几乎不溶于水。常温常压下较稳定,对强酸、强碱及氟离子敏感,因含有叔丁基二甲基硅烷基(TBS)保护基。建议避光密封低温储存。
外观
类白色至白色结晶粉末
纯度
≥98%(HPLC)
溶解性
溶于二氯甲烷、甲醇、乙酸乙酯等有机溶剂,不溶于水
储存条件
2-8°C避光密封保存
English description(英文原文,共 1628 字符)
Product Name:2S,4R-4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-N-[(1S,2S)-2-hydroxy-1,2-diphenylethyl]-2-pyrrolidinecarboxamide

English Name:2S,4R-4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-N-[(1S,2S)-2-hydroxy-1,2-diphenylethyl]-2-pyrrolidinecarboxamide

CAS No.:933787-22-5

Aliases:(2S,4R)-4-((tert-Butyldimethylsilyl)oxy)-N-((1S,2S)-2-hydroxy-1,2-diphenylethyl)pyrrolidine-2-carboxamide, TBS-protected (2S,4R)-4-hydroxyproline amide derivative

Molecular Formula:C25H36N2O3Si

Physical Properties:Off-white to white crystalline powder; molecular weight 440.65. Soluble in dichloromethane, chloroform, ethyl acetate and methanol; practically insoluble in water. Stable under normal conditions, but sensitive to strong acid, strong base and fluoride ions due to the TBS protecting group. Store protected from light in a sealed container at low temperature.

Uses:This compound is a chiral pyrrolidinecarboxamide intermediate containing a TBS protecting group, mainly used in the synthesis of polysubstituted pyrrolidines, proline derivatives and other nitrogen-containing heterocycles. It serves as a chiral building block in pharmaceutical research and participates in amide coupling, deprotection and derivatization reactions for the preparation of enzyme inhibitors and receptor ligand drug candidates.

Technical Specifications:

Molecular formula: C25H36N2O3Si; Molecular weight: 440.65

Appearance: off-white to white crystalline powder

Purity: ≥98% (HPLC)

Solubility: soluble in dichloromethane, methanol, ethyl acetate and other organic solvents; insoluble in water

Storage: store sealed at 2-8°C protected from light
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常见问题

2S,4R-4-[[(1,1-DIMETHYLETHYL)DIMETHYLSILYL]OXY]-N- (933787-2的 CAS 号是多少?
2S,4R-4-[[(1,1-DIMETHYLETHYL)DIMETHYLSILYL]OXY]-N- (933787-2的 CAS 号是 933787-22-5。
2S,4R-4-[[(1,1-DIMETHYLETHYL)DIMETHYLSILYL]OXY]-N- (933787-2的分子式和分子量是什么?
2S,4R-4-[[(1,1-DIMETHYLETHYL)DIMETHYLSILYL]OXY]-N- (933787-2的分子式为 C25H36N2O3Si。
2S,4R-4-[[(1,1-DIMETHYLETHYL)DIMETHYLSILYL]OXY]-N- (933787-2的英文名称是什么?
2S,4R-4-[[(1,1-DIMETHYLETHYL)DIMETHYLSILYL]OXY]-N- (933787-2的英文名称为 2S,4R-4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-N-[(1S,2S)-2-hydroxy-1,2-diphenylethyl]-2-pyrrolidinecarboxamide。
2S,4R-4-[[(1,1-DIMETHYLETHYL)DIMETHYLSILYL]OXY]-N- (933787-2还有哪些别名?
2S,4R-4-[[(1,1-DIMETHYLETHYL)DIMETHYLSILYL]OXY]-N- (933787-2又称 (2S,4R)-4-(叔丁基二甲基硅氧基)-N-[(1S,2S)-2-羟基-1,2-二苯基乙基]吡咯烷-2-甲酰胺、TBS保护的(2S,4R)-4-羟基脯氨酸酰胺衍生物。
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