泊那替尼盐酸盐 (CAS No.1114544-31-8)
- 物化性质
- 白色至类白色固体粉末，分子量约569.03。可溶于DMSO和甲醇，微溶于水。
- 技术参数
- 纯度≥98%（HPLC） 外观为白色至类白色固体粉末 可溶于DMSO和甲醇，微溶于水 对Abl、PDGFRα、VEGFR2、FGFR1和Src的IC50分别为0.37 nM、1.1 nM、1.5 nM、2.2 nM和5.4 nM 建议-20°C避光、密封保存
English description（英文原文，共 1084 字符）
Product Name:Ponatinib Hydrochloride
English Name:Ponatinib Hydrochloride
CAS No.:1114544-31-8
Aliases:Ponatinib Monohydrochloride, AP24534
Molecular Formula:C29H28ClF3N6O
Physical Properties:White to off-white solid powder, molecular weight approximately 569.03. Soluble in DMSO and methanol, slightly soluble in water.
Uses:Ponatinib hydrochloride is the hydrochloride salt form of ponatinib, a potent and orally active multi-targeted kinase inhibitor. It inhibits Abl, PDGFRα, VEGFR2, FGFR1, and Src with IC50 values of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM, respectively. Clinically, it is used to treat chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia that are resistant or intolerant to prior therapy.
Technical Specifications:
Purity ≥98% (HPLC)
Appearance: white to off-white solid powder
Soluble in DMSO and methanol, slightly soluble in water
IC50 values for Abl, PDGFRα, VEGFR2, FGFR1, and Src are 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM respectively
Recommended storage: sealed, protected from light at -20°C
English Name:Ponatinib Hydrochloride
CAS No.:1114544-31-8
Aliases:Ponatinib Monohydrochloride, AP24534
Molecular Formula:C29H28ClF3N6O
Physical Properties:White to off-white solid powder, molecular weight approximately 569.03. Soluble in DMSO and methanol, slightly soluble in water.
Uses:Ponatinib hydrochloride is the hydrochloride salt form of ponatinib, a potent and orally active multi-targeted kinase inhibitor. It inhibits Abl, PDGFRα, VEGFR2, FGFR1, and Src with IC50 values of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM, respectively. Clinically, it is used to treat chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia that are resistant or intolerant to prior therapy.
Technical Specifications:
Purity ≥98% (HPLC)
Appearance: white to off-white solid powder
Soluble in DMSO and methanol, slightly soluble in water
IC50 values for Abl, PDGFRα, VEGFR2, FGFR1, and Src are 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM respectively
Recommended storage: sealed, protected from light at -20°C
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常见问题
- 泊那替尼盐酸盐的 CAS 号是多少？
- 泊那替尼盐酸盐的 CAS 号是 1114544-31-8。
- 泊那替尼盐酸盐的分子式和分子量是什么？
- 泊那替尼盐酸盐的分子式为 C29H28ClF3N6O。
- 泊那替尼盐酸盐的英文名称是什么？
- 泊那替尼盐酸盐的英文名称为 Ponatinib Hydrochloride。
- 泊那替尼盐酸盐还有哪些别名？
- 泊那替尼盐酸盐又称 普纳替尼单盐酸盐、AP24534。
- 泊那替尼盐酸盐有哪些供应商和生产厂家？
- 掌上化工当前收录 1 条泊那替尼盐酸盐供应报价，来自 1 家供应商，可按地区、纯度、级别筛选对比。
- 泊那替尼盐酸盐的供应商主要分布在哪些地区？
- 泊那替尼盐酸盐的供应商主要分布在 上海市（1 条） 等地。
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- 平台上泊那替尼盐酸盐的供应级别包括 工业级。
- 泊那替尼盐酸盐的报价单位是什么？
- 泊那替尼盐酸盐的报价单位主要有 千克。
- 哪里可以查到泊那替尼盐酸盐的价格？
- 掌上化工泊那替尼盐酸盐产品页汇总了各供应商的最新报价与规格，地址：/chemicals/1114544-31-8/。部分供应商价格为电议，可通过页面上的询价功能直接获取。
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