1,3-二-O-(叔-丁基二甲基硅烷基)卡泊三醇 (CAS No.112875-61-3)

Product Name:1,3-Di-O-(tert-butyldimethylsilyl)calcipotriol

English Name:1,3-Di-O-(tert-butyldimethylsilyl)calcipotriol

CAS No.:112875-61-3

Aliases:1,3-Bis-O-(tert-butyldimethylsilyl)calcipotriol, Calcipotriol bis-TBS ether, 1,3-Di-TBS-calcipotriol

Molecular Formula:C39H68O3Si2

Physical Properties:White to off-white crystalline powder; soluble in organic solvents such as dichloromethane, ethyl acetate, methanol, and chloroform, nearly insoluble in water; sensitive to acid, the tert-butyldimethylsilyl protecting groups can be removed under acidic conditions; should be stored sealed, protected from light, and kept at low temperature in a dry environment.

Uses:Used as a key hydroxyl-protecting intermediate in the synthesis of calcipotriol and other vitamin D derivatives. The TBS group selectively protects the 1,3-hydroxy groups of calcipotriol for multi-step synthesis, with the target drug obtained by final deprotection. Also applicable to the preparation of other vitamin D analogs.

Technical Specifications:

Appearance: white to off-white powder.

Purity: HPLC purity not less than 95%.

Molecular weight: 640.05 (calculated as C39H68O3Si2).

Storage: sealed, stored at 2-8°C protected from light.

Solubility: readily soluble in dichloromethane, ethyl acetate, methanol, and chloroform.