N-[(2S)-2-[[(甲基]-1-氧代-3-苯基丙基]-甘氨酸乙酯 (CAS No.1314751-85-3)

Product Name:N-[(2S)-2-[[(Methylsulfonyl)oxy]methyl]-1-oxo-3-phenylpropyl]glycine ethyl ester

English Name:N-[(2S)-2-[[(Methylsulfonyl)oxy]methyl]-1-oxo-3-phenylpropyl]glycine ethyl ester

CAS No.:1314751-85-3

Aliases:Ethyl N-[(2S)-2-[(methanesulfonyloxy)methyl]-1-oxo-3-phenylpropyl]glycinate, (2S)-2-[(Methanesulfonyloxy)methyl]-N-(2-ethoxy-2-oxoethyl)-3-phenylpropanamide, Ethyl 2-((2S)-2-[(mesyloxy)methyl]-3-phenylpropanamido)acetate

Molecular Formula:C15H21NO6S

Physical Properties:White to off-white solid powder at room temperature; density approximately 1.20 g/cm³; estimated boiling point about 550°C (predicted, may decompose), with a relatively high flash point. Freely soluble in organic solvents such as dichloromethane, methanol and ethyl acetate; insoluble in water. The molecule contains a (2S)-chiral center and a mesyloxy leaving group. Moisture-sensitive; store sealed and protected from light at -20°C in a dry environment.

Uses:This compound is an important intermediate in chiral pharmaceutical synthesis. The mesyloxy (-OMs) group within its molecule is an excellent leaving group, allowing the introduction of amino, azido, halogen and other functional groups via nucleophilic substitution reactions. It is mainly used for preparing chiral amino acid derivatives, unnatural amino acids and peptide analogues, and is widely applied in medicinal chemistry and organic synthesis for constructing bioactive molecules containing the phenylalanine skeleton.

Technical Specifications:

Molecular formula: C15H21NO6S; molecular weight: 343.4 g/mol

Optical purity: ee ≥ 98% (single S-configuration)

HPLC assay: ≥ 95%

Solubility: soluble in dichloromethane, methanol and ethyl acetate; insoluble in water

Storage: keep sealed, dry and protected from light at -20°C