DBCO-四乙酰甘露糖胺 (CAS No.1369862-03-2)
- 中文别名
- 二苯并环辛炔-四乙酰甘露糖胺；DBCO-四乙酰基甘露糖胺；DBCO-ManNAc；四乙酰甘露糖胺-DBCO偶联物
- 英文名称
- DBCO-Tetraacetylmannosamine
- 分子式
- C32H34N2O11
- 所属类别
- 中间体
- 物化性质
- 白色至类白色固体。可溶于DMSO、DMF、二氯甲烷等有机溶剂，不溶于水。四乙酰基保护基团赋予分子良好的脂溶性，能有效穿透细胞膜；进入细胞后乙酰基被胞内酯酶水解释放，得到具有代谢活性的甘露糖胺衍生物。需在-20℃干燥、避光条件下保存。
- 纯度
- ≥95%（HPLC）
- 外观
- 白色至类白色固体
- 溶解性
- 易溶于DMSO、DMF、二氯甲烷等有机溶剂
- 储存条件
- -20℃避光、干燥保存，避免反复冻融
English description（英文原文，共 1873 字符）
Product Name:DBCO-Tetraacetylmannosamine
English Name:DBCO-Tetraacetylmannosamine
CAS No.:1369862-03-2
Aliases:DBCO-Ac4ManNAc, Dibenzocyclooctyne-tetraacetylmannosamine, ADIBO-tetraacetylmannosamine, DBCO-modified mannosamine tetraacetate
Molecular Formula:C32H34N2O11
Physical Properties:White to off-white solid. Soluble in DMSO, DMF, dichloromethane and other organic solvents; insoluble in water. The tetraacetyl groups confer high lipophilicity, allowing efficient penetration across cell membranes. Once internalized, the acetyl groups are hydrolyzed by intracellular esterases to release the metabolically active mannosamine derivative. Store at -20°C in a dry, light-protected environment.
Uses:This peracetylated mannosamine derivative bearing a dibenzocyclooctyne (DBCO) group is designed for metabolic oligosaccharide engineering and bioorthogonal labeling. After cellular uptake, intracellular esterases remove the acetyl groups, and the released mannosamine derivative enters the sialic acid biosynthetic pathway, displaying DBCO groups on sialic acid residues of cell-surface glycoproteins and glycolipids. The DBCO groups react efficiently with azide-labeled fluorophores, biotin, or affinity probes via strain-promoted azide-alkyne cycloaddition (SPAAC, copper-free click chemistry), enabling cell-surface glycan imaging, glycoproteomic profiling, and targeted delivery applications. Compared with azide-based sugar probes, this probe avoids the issue of azide reduction by endogenous species and is thus better suited for in vivo labeling.
Technical Specifications:
Formula: C32H34N2O11; Molecular weight: 622.62
Purity: ≥95% (HPLC)
Appearance: white to off-white solid
Solubility: freely soluble in DMSO, DMF, dichloromethane and other organic solvents
Storage: store at -20°C in a dry, light-protected place; avoid repeated freeze-thaw cycles
English Name:DBCO-Tetraacetylmannosamine
CAS No.:1369862-03-2
Aliases:DBCO-Ac4ManNAc, Dibenzocyclooctyne-tetraacetylmannosamine, ADIBO-tetraacetylmannosamine, DBCO-modified mannosamine tetraacetate
Molecular Formula:C32H34N2O11
Physical Properties:White to off-white solid. Soluble in DMSO, DMF, dichloromethane and other organic solvents; insoluble in water. The tetraacetyl groups confer high lipophilicity, allowing efficient penetration across cell membranes. Once internalized, the acetyl groups are hydrolyzed by intracellular esterases to release the metabolically active mannosamine derivative. Store at -20°C in a dry, light-protected environment.
Uses:This peracetylated mannosamine derivative bearing a dibenzocyclooctyne (DBCO) group is designed for metabolic oligosaccharide engineering and bioorthogonal labeling. After cellular uptake, intracellular esterases remove the acetyl groups, and the released mannosamine derivative enters the sialic acid biosynthetic pathway, displaying DBCO groups on sialic acid residues of cell-surface glycoproteins and glycolipids. The DBCO groups react efficiently with azide-labeled fluorophores, biotin, or affinity probes via strain-promoted azide-alkyne cycloaddition (SPAAC, copper-free click chemistry), enabling cell-surface glycan imaging, glycoproteomic profiling, and targeted delivery applications. Compared with azide-based sugar probes, this probe avoids the issue of azide reduction by endogenous species and is thus better suited for in vivo labeling.
Technical Specifications:
Formula: C32H34N2O11; Molecular weight: 622.62
Purity: ≥95% (HPLC)
Appearance: white to off-white solid
Solubility: freely soluble in DMSO, DMF, dichloromethane and other organic solvents
Storage: store at -20°C in a dry, light-protected place; avoid repeated freeze-thaw cycles
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| 产品名称 | 纯度 | 包装规格 | 级别 | 价格 | 库存 | 操作 |
|---|---|---|---|---|---|---|
| DBCO-四乙酰甘露糖胺 CAS 1369862-03-2 | ≥95%（HPLC） | — | 工业级 | 电议 | — | 询价 |
常见问题
- DBCO-四乙酰甘露糖胺的 CAS 号是多少？
- DBCO-四乙酰甘露糖胺的 CAS 号是 1369862-03-2。
- DBCO-四乙酰甘露糖胺的分子式和分子量是什么？
- DBCO-四乙酰甘露糖胺的分子式为 C32H34N2O11。
- DBCO-四乙酰甘露糖胺的英文名称是什么？
- DBCO-四乙酰甘露糖胺的英文名称为 DBCO-Tetraacetylmannosamine。
- DBCO-四乙酰甘露糖胺还有哪些别名？
- DBCO-四乙酰甘露糖胺又称 二苯并环辛炔-四乙酰甘露糖胺、DBCO-四乙酰基甘露糖胺、DBCO-ManNAc、四乙酰甘露糖胺-DBCO偶联物。
- DBCO-四乙酰甘露糖胺有哪些供应商和生产厂家？
- 掌上化工当前收录 1 条DBCO-四乙酰甘露糖胺供应报价，来自 1 家供应商，可按地区、纯度、级别筛选对比。
- DBCO-四乙酰甘露糖胺的供应商主要分布在哪些地区？
- DBCO-四乙酰甘露糖胺的供应商主要分布在 上海市（1 条） 等地。
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- 平台上DBCO-四乙酰甘露糖胺的供应级别包括 工业级。
- DBCO-四乙酰甘露糖胺的报价单位是什么？
- DBCO-四乙酰甘露糖胺的报价单位主要有 千克。
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- 掌上化工DBCO-四乙酰甘露糖胺产品页汇总了各供应商的最新报价与规格，地址：/chemicals/1369862-03-2/。部分供应商价格为电议，可通过页面上的询价功能直接获取。
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