N-BOC-1H-吲哚-6-羧酸甲酯 (CAS No.957127-83-2)

Product Name:N-BOC-1H-INDOLE-6-CARBOXYLIC ACID METHYL ESTER

English Name:N-BOC-1H-INDOLE-6-CARBOXYLIC ACID METHYL ESTER

CAS No.:957127-83-2

Aliases:Methyl 1-BOC-1H-indole-6-carboxylate, tert-Butyl 6-(methoxycarbonyl)-1H-indole-1-carboxylate, 1-(tert-Butoxycarbonyl)-1H-indole-6-carboxylic acid methyl ester

Molecular Formula:C15H17NO3

Physical Properties:White to off-white solid. Predicted density: approximately 1.19 g/cm³. Predicted boiling point: approximately 365.2°C at 760 mmHg. Soluble in common organic solvents such as dichloromethane, ethyl acetate, and chloroform; insoluble in water. The BOC protecting group can be removed under strong acidic conditions or upon heating; store sealed in a dry environment.

Uses:Primarily used as an intermediate in organic synthesis and medicinal chemistry to introduce the N-BOC-protected indole-6-carboxylate methyl ester moiety. This compound is a key precursor for the synthesis of tryptamine derivatives, indole alkaloids, and various bioactive molecules bearing indole scaffolds, including certain receptor antagonists and kinase inhibitors. It is also widely employed to construct the core structural fragment of polysubstituted indole-based target compounds.

Technical Specifications:

Molecular weight: 259.30

Appearance: white to off-white crystalline powder

Purity: ≥98% (HPLC)

Melting point range: typically 130-135°C (varies slightly with purity)

Storage conditions: keep tightly sealed, protected from light, store refrigerated at 2-8°C