6-氟-ALPHA-甲基吡啶-3-甲胺 (CAS No.905587-45-3)

Product Name:1-(6-Fluoropyridin-3-yl)ethanamine

English Name:1-(6-Fluoropyridin-3-yl)ethanamine

CAS No.:905587-45-3

Aliases:6-Fluoro-α-methyl-3-pyridinemethanamine, (6-Fluoropyridin-3-yl)-α-methylmethylamine, 1-(6-Fluoropyridin-3-yl)ethylamine

Molecular Formula:C7H9FN2

Physical Properties:Colorless to light yellow transparent liquid with a characteristic amine odor. Boiling point approximately 200-210°C (760 mmHg), flash point approximately 87°C. Density approximately 1.10 g/cm³ (25°C). Slightly soluble in water; soluble in common organic solvents such as ethanol, diethyl ether, and dichloromethane. Exhibits typical primary amine reactivity including acylation, alkylation, and salt formation; the fluorinated pyridine ring imparts favorable metabolic stability and lipophilicity.

Uses:This compound serves as a key intermediate in the pharmaceutical synthesis of fluorinated pyridine-containing drugs, particularly applicable to the molecular construction of kinase inhibitors and central nervous system agents. It is also utilized as an active structural unit in the synthesis of agrochemical fungicides and herbicides, and functions as a building block for introducing fluoropyridyl groups in organic synthesis for new compound screening and research.

Technical Specifications:

Assay (HPLC) ≥ 97%, water content ≤ 0.50%, enantiomeric purity (if applicable) ≥ 99.0% e.e.

Appearance: colorless to light yellow transparent liquid, free of visible insoluble matter or mechanical impurities.

Boiling range approximately 200-210°C (760 mmHg), flash point approximately 87°C (closed cup).

Density approximately 1.10 g/cm³ (25°C), refractive index approximately 1.500-1.520 (20°C).

Solubility: slightly soluble in water; miscible with organic solvents such as ethanol, diethyl ether, and dichloromethane in all proportions.